A Dynamic Stochastic Model for DNA Replication Initiation in Early Embryos
نویسندگان
چکیده
منابع مشابه
A Dynamic Stochastic Model for DNA Replication Initiation in Early Embryos
BACKGROUND Eukaryotic cells seem unable to monitor replication completion during normal S phase, yet must ensure a reliable replication completion time. This is an acute problem in early Xenopus embryos since DNA replication origins are located and activated stochastically, leading to the random completion problem. DNA combing, kinetic modelling and other studies using Xenopus egg extracts have...
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is generally believed that the sex chromatin which is found in the cells of 'Lammalian Eemales represents a genetically inactive X chromosome (LYON 1961 ; RUSSELL 1961 ) iwhich is heterochromatic and is replicated out of synchrony with the other X (ATKINS, TAFT and DALAL 1962; GRUMBACH, MORISHIMA and TAYLOR 1963; OHNO and CATTANACH 1962). According to the single-active-X hypothesis, inactivatio...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2008
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0002919